Skin Micrograph Protector in a Burn Wound: Alloderm or Hydrogel Coating?

AIM OF STUDY Was to compare the dynamics of engraftment skin micrographs in a burn wound when using protectors from an allodermal graft and hydrogel coating. MATERIAL AND METHODS The experimental study was conducted on 18 rats with scab formed 3 days after modeling deep area 20% body surface. Partial fascial necrectomy performed: two rounded sections sling diameter 25 mm were excised. 6 automicrographs 4x4 mm, 0.3 thick, applied each surface freed scab. In animal, one wounds covered protector, other allodermotransplant another animal group. A secondary aseptic dressing protectors. On 5th 20th operation, state studied: blood circulation — according laser Doppler flowmetry, microstructure vivo optical coherence tomography, ex histological examination biopsies. ReSUlTS Differences rate restoration early stages postoperative period found. first 5 days, perfusion under protector exceeded indicator coating by 44 [21; 51] % (p=0.031) due contribution endothelial neurogenic mechanisms flow modulation. Starting day 10, differences levelled, but there signs more active regulation (p=0.028). Histologically, appearance full-blooded capillaries revealed earlier alloderm than protector. By 20 condition regular change coatings, healing studied coatings did not significantly differ. However, structure integumentary tissue tomography data closer normal CONClUSIONS From point view physiology process, is preferred option autograft comparison coating, which probably paracrine biological activity alloderm. can provide comparable level efficiency, provided they are regularly changed and, potentially, given properties cytokine activity.